Treatment-resistant depression (TRD) is a form of major depression that doesn’t typically respond to conventional forms of treatment such as therapy or oral antidepressant. It also refers to a condition in which an individual experiences persistent symptoms of depression despite multiple attempts to treat them with standard interventions. Even though treatment-resistant depression is a challenging condition, it’s imperative for persons with TRD to seek specialized care to manage their symptoms.

Symptoms of TRD

While these depression symptoms resemble that of major depressive depression, this type of depression is usually unresponsive to oral antidepressants. For persons with treatment-resistant depression, their symptoms persist despite several attempts to treat them. This could lead to feelings of despair and frustration.

  • Appetite and weight changes
  • Thoughts of suicide or self-harm
  • Feelings of hopelessness, sadness, and worthlessness
  • Fatigue and a lack of energy
  • Difficulty sleeping or oversleeping
  • Loss of interest in activities that you once enjoyed

It’s essential for persons with this form of depression to seek specialized care to help manage their symptoms. The professionals at Pharmasite Research can analyze the person’s symptoms and develop a personalized treatment program. Overall, individuals with TRD can learn to manage their symptoms and enhance their life quality with the proper support and treatment.

Causes of TRD

Since TRD is a complex condition with various potential causes, here are the common causes.

  • Biological factors: This can include imbalances in neurotransmitter levels, genetic factors, and structural changes in the brain.
  • Environmental: Exposure to stressful or traumatic life events can trigger or worsen depression symptoms. For persons with TRD, these environmental factors might play a role in their persistent symptoms.
  • Psychological: These include negative thought patterns, low self-esteem, or a history of trauma or abuse. So, these psychological factors can make it challenging for persons with TRD to respond to treatment.
  • Combination of factors: It’s also possible that a combination of all factors mentioned above contributes to treatment-resistant depression.

Although the causes of TRD are often multifaceted, they differ from person to person. However, it’s crucial for persons with TRD to seek specialized care to help identify which factors contribute to the depressive symptoms they experience. By understanding this depression disorder, our mental health professionals can create an effective treatment plan to help you manage your symptoms and enhance your quality of life.

Enroll Today with Pharmasite Research

If you or someone you know is suffering from depression, it can be a huge hindrance to daily life, but there is always hope and help available. Seek professional help from a therapist who may recommend effective treatment options for you or a loved one. Pharmasite Research in Pikesville, MD, is enrolling individuals with depression for a clinical study. Learn more to see if you qualify! Contact us at 410-602-1440 and follow us on Facebook, Twitter, and Pinterest!