Biopolar Depression PicBipolar disorder, also known as manic depression, is a serious psychiatric disorder characterized by mood shifts. Approximately 5.7 million adults in the U.S. are affected. While Bipolar I Disorder and Bipolar II Disorder are differentiated by whether manic/mixed episodes or hypomania occurs, both classes are often associated with major depressive episodes. In fact, bipolar depression is the most common presentation of bipolar disorder. Depressive episodes associated with bipolar disorder usually last longer, recur more frequently, and have a worse prognosis than manic/hypomanic episodes.

Symptoms Can Include:

  • A pattern of changes in mood, energy, and activity levels
  • Manic episodes can consist of:
    • Feeling very “up”, “high”, or elated
    • Increased energy or activity levels
    • Trouble sleeping
    • Racing thoughts
    • Agitation or irritability
    • Doing risky things such as spending a lot of money
  • Depressive episodes can consist of:
    • Feeling sad, down, empty, and hopeless
    • Decreased energy or activity levels
    • Trouble sleeping or concentrating
    • Changes in appetite
    • Feeling fatigued or empty

Several Risk Factors Include:

  • Relatives with bipolar disorder (i.e. heredity)
  • Brain structure and functioning
  • Genetics

Participate in Research Studies for Bipolar Depression

  • Receive study-related care and examinations at no cost to you
  • Study-related medications are at no cost to you if eligible
  • Compensation for your time and travel

You may qualify for a study if you:

  • Are between 18-75 years old and have bipolar disorder
  • Have been experiencing depressive symptoms for the past 2 weeks or longer
  • Are taking lithium or Depakote with little to no response, or
  • Have not taken medication(s) for your bipolar depression, or
  • Have not been unresponsive to more than one medication for your bipolar depression

Citation: Intra-Cellular Therapies, Inc., and National Institute of Mental Health

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